About the Authors

Andrea Weghofer

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Department of Gynecological Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria

Muy-Kheng Tea

Affiliation Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria

David H. Barad

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Foundation for Reproductive Medicine, New York, New York, United States of America

Ann Kim

Affiliation The Center for Human Reproduction, New York, New York, United States of America

Christian F. Singer

Affiliation Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria

Klaus Wagner

Affiliation Department of Human Genetics, Medical University Graz, Graz, Austria

Norbert Gleicher

ngleicher@thechr.com

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Foundation for Reproductive Medicine, New York, New York, United States of America

Competing Interests

N.G., A.W. and D.H.B. have in the past received research support, speakers’ honoraria and travel funds from EDM Serono (now Merck-Serono), Organon Pharmaceutical (now Schering Plough), Ferring Pharmaceuticals and Bard Medical, none, however, related to the subject of this paper. N.G. and D.H.B. are listed as co-inventors on pending U.S. patent applications, claiming diagnostic benefits from determining of ovarian FMR1 genotypes and sub-genotypes in association with female infertility. The patent claims are (1) Diagnostic relevance of CGG repeat numbers on the FMR1 gene in predicting functional ovarian reserve over time (i.e., ovarian aging patterns); (2) Newly described, so-called “ovarian” genotypes and sub-genotypes, based on a normal range of 26–34 CGG repeats as “normal” range; (3) Diagnostic relevance of these newly described genotypes and sub-genotypes in defining specific ovarian aging patterns and relevance to defining autoimmune risk. N.G. is the owner of The CHR, and A.K. and D.H.B. are employed there. A.W. is an associate visiting scientist at The CHR. The CHR was a funder of this study and where this research was conducted. The medical corporation, however, exerted no influence on this study. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AW DHB NG. Performed the experiments: DHB AK. Analyzed the data: DHB AK AW NG. Contributed reagents/materials/analysis tools: MKT CFS KW. Wrote the paper: NG. Contributed to availability of Austrian patient data: MKT CFS KW. Coordination between Austrian and US investigators: AW.