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Research Article

Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis

  • Chuanfu Li,

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Fang Hua,

    Affiliation: Department of Emergency Medicine, Emory University School of Medicine Atlanta, Georgia, United States of America

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  • Tuanzhu Ha,

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Krishna Singh,

    Affiliation: Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Chen Lu,

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • John Kalbfleisch,

    Affiliation: Department of Biometry and Medical Computing, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Kevin F. Breuel,

    Affiliation: Department of Obstetrics and Gynecology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Tiffany Ford,

    Affiliation: Department of Obstetrics and Gynecology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Race L. Kao,

    Affiliations: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America, Department of Emergency Medicine, Emory University School of Medicine Atlanta, Georgia, United States of America

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  • Ming Gao,

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Tammy R. Ozment,

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • David L. Williams mail

    williamd@etsu.edu

    Affiliation: Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

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  • Published: September 19, 2012
  • DOI: 10.1371/journal.pone.0044712

About the Authors

Chuanfu Li, Tuanzhu Ha, Chen Lu, Race L. Kao, Ming Gao, Tammy R. Ozment, David L. Williams
Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
Fang Hua, Race L. Kao
Department of Emergency Medicine, Emory University School of Medicine Atlanta, Georgia, United States of America
Krishna Singh
Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
John Kalbfleisch
Department of Biometry and Medical Computing, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
Kevin F. Breuel, Tiffany Ford
Department of Obstetrics and Gynecology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America

Corresponding Author

Email: williamd@etsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C. Li FH KS DLW. Performed the experiments: FH TH C. Lu KB TF RK MG TRO. Analyzed the data: C. Li TH JK KS DLW. Contributed reagents/materials/analysis tools: C. Li KS KB RK DLW. Wrote the paper: C. Li FH JK DLW.