Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Chaohui Duan; Luchang Zhu; Ying Xu; Gee W. Lau

doi:10.1371/journal.pone.0044710

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Open Access

Peer-reviewed

Research Article

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Chaohui Duan ,

Contributed equally to this work with: Chaohui Duan, Luchang Zhu

Affiliations Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Laboratory of Clinical Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Luchang Zhu ,

Contributed equally to this work with: Chaohui Duan, Luchang Zhu

Affiliation Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Ying Xu,

Affiliations Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Laboratory of Clinical Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
⨯
Gee W. Lau

* E-mail: geelau@illinois.edu

Affiliation Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
⨯

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Chaohui Duan,
Luchang Zhu,
Ying Xu,
Gee W. Lau

Published: September 13, 2012
https://doi.org/10.1371/journal.pone.0044710

About the Authors

Chaohui Duan

Contributed equally to this work with: Chaohui Duan, Luchang Zhu

Affiliations Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Laboratory of Clinical Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China

Luchang Zhu

Contributed equally to this work with: Chaohui Duan, Luchang Zhu

Affiliation Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Ying Xu

Gee W. Lau

* E-mail: geelau@illinois.edu

Affiliation Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHD LZ GWL. Performed the experiments: CHD LZ YX. Analyzed the data: CHD LZ YX GWL. Contributed reagents/materials/analysis tools: CHD LZ YX GWL. Wrote the paper: LZ GWL.

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Genetic transformation
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Glutamate
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Pneumococcus
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Antibiotic resistance
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Regulons
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Streptomycin
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Amino acid substitution
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Horizontal gene transfer
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