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Research Article

Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway

  • Kai Connie Wu equal contributor,

    equal contributor Contributed equally to this work with: Kai Connie Wu, Peter R. McDonald

    Affiliation: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America

    X
  • Peter R. McDonald equal contributor,

    equal contributor Contributed equally to this work with: Kai Connie Wu, Peter R. McDonald

    Affiliation: University of Kansas High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, United States of America

    X
  • Jie Jerry Liu,

    Affiliation: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Rathnam Chaguturu,

    Affiliation: Center for Advanced Drug Research, SRI International, Harrisonburg, Virginia, United States of America

    X
  • Curtis D. Klaassen mail

    cklaasse@kumc.edu

    Affiliation: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America

    X
  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0044686

About the Authors

Kai Connie Wu
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Peter R. McDonald
University of Kansas High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, United States of America
Jie Jerry Liu, Curtis D. Klaassen
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Rathnam Chaguturu
Center for Advanced Drug Research, SRI International, Harrisonburg, Virginia, United States of America

Corresponding Author

Email: cklaasse@kumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: PM JL KW RC. Analyzed the data: PM JL KW CK. Contributed reagents/materials/analysis tools: RC. Wrote the paper: KW PM CK. Conceived the experiments: CK KW. Designed the experiments: PM CK KW.