About the Authors

Kirsi Kujala

Contributed equally to this work with: Kirsi Kujala, Jere Paavola

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland

Jere Paavola

Contributed equally to this work with: Kirsi Kujala, Jere Paavola

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland, Minerva Foundation Institute for Medical Research, Helsinki, Finland

Anna Lahti

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland

Kim Larsson

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland

Mari Pekkanen-Mattila

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland

Matti Viitasalo

Affiliation Department of Cardiology, Helsinki University Hospital, Helsinki, Finland

Annukka M. Lahtinen

Affiliation Research Program’s Unit Molecular Medicine, University of Helsinki, Helsinki, Finland

Lauri Toivonen

Affiliation Department of Cardiology, Helsinki University Hospital, Helsinki, Finland

Kimmo Kontula

Affiliation Department of Medicine, University of Helsinki, Helsinki, Finland

Heikki Swan

Affiliation Department of Medicine, University of Helsinki, Helsinki, Finland

Mika Laine

Affiliations Minerva Foundation Institute for Medical Research, Helsinki, Finland, Department of Cardiology, Helsinki University Hospital, Helsinki, Finland

Olli Silvennoinen

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland, Tampere University Hospital, Tampere, Finland

Katriina Aalto-Setälä

katriina.aalto-setala@uta.fi

Affiliations Institute of Biomedical Technology, University of Tampere, Tampere, Finland, BioMediTech, Tampere, Finland, Heart Center, Tampere, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Kujala JP KL K. Kontula OS KAS. Performed the experiments: K. Kujala JP AL KL MV AML. Analyzed the data: K. Kujala JP KL MPM MV LT ML OS KAS. Contributed reagents/materials/analysis tools: OS KAS. Wrote the paper: K. Kujala JP KL KAS. Clinical expertise: LT K. Kontula HS ML. Genetic expertise: K. Kontula HS. Provided genotyped patients: K. Kontula.