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Research Article

Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer

  • Yasusei Kudo mail,

    yasusei@tokushima-u.ac.jp (YK); ttakata@hiroshima-u.ac.jp (TT)

    Affiliations: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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  • Shinji Iizuka,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Maki Yoshida,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Phuong Thao Nguyen,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Samadarani B. S. M. Siriwardena,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Takaaki Tsunematsu,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Mariko Ohbayashi,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Toshinori Ando,

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Daijiro Hatakeyama,

    Affiliation: Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan

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  • Toshiyuki Shibata,

    Affiliation: Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan

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  • Keiichi Koizumi,

    Affiliation: Department of Kampo Diagnostic, Institute of Natural Medicine, University of Toyama, Toyama, Japan

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  • Masahiro Maeda,

    Affiliation: Department of Research and Development, Immuno-Biological Laboratories, Co., Ltd., Fujioka-shi, Gunma, Japan

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  • Naozumi Ishimaru,

    Affiliation: Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

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  • Ikuko Ogawa,

    Affiliation: Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan

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  • Takashi Takata mail

    yasusei@tokushima-u.ac.jp (YK); ttakata@hiroshima-u.ac.jp (TT)

    Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pone.0044488

About the Authors

Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Phuong Thao Nguyen, Samadarani B. S. M. Siriwardena, Takaaki Tsunematsu, Mariko Ohbayashi, Toshinori Ando, Takashi Takata
Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Daijiro Hatakeyama, Toshiyuki Shibata
Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan
Keiichi Koizumi
Department of Kampo Diagnostic, Institute of Natural Medicine, University of Toyama, Toyama, Japan
Masahiro Maeda
Department of Research and Development, Immuno-Biological Laboratories, Co., Ltd., Fujioka-shi, Gunma, Japan
Ikuko Ogawa
Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan
Yasusei Kudo, Naozumi Ishimaru
Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Corresponding Authors

Competing Interests

Author Masahiro Maeda is employed by Immuno-Biological Laboratories, Co., Ltd. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YK. Performed the experiments: YK SI MY PTN SBSMS T. Tsunematsu MO TA. Analyzed the data: YK SI MY PTN NI IO T. Takata. Contributed reagents/materials/analysis tools: YK PTN SBSMS DH TS KK MM. Wrote the paper: YK. Obtained permission for use of cell line: KK.