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Research Article

Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses

  • Stephanie C. J. Keating,

    Affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Aurelie A. Thomas,

    Affiliation: Institute of Neuroscience and Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Paul A. Flecknell,

    Affiliation: Institute of Neuroscience and Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Matthew C. Leach mail

    Matthew.Leach@Newcastle.ac.uk

    Affiliation: Institute of Neuroscience and Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Published: September 07, 2012
  • DOI: 10.1371/journal.pone.0044437

About the Authors

Stephanie C. J. Keating
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Aurelie A. Thomas, Paul A. Flecknell, Matthew C. Leach
Institute of Neuroscience and Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

Corresponding Author

Email: Matthew.Leach@Newcastle.ac.uk

Competing Interests

The authors have declared that no competing interests exist. The commercial organisation Harlan UK donated the animals used in the study. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MCL AAT PAF. Performed the experiments: MCL AAT MCL. Analyzed the data: MCL SCJK. Wrote, read, edited and approved the final manuscript: SCJK AAT PAF MCL.