About the Authors

Steven John Kiddle

steven.kiddle@kcl.ac.uk (SJK); richard.j.dobson@kcl.ac.uk (RD)

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Madhav Thambisetty

Affiliation Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America

Andrew Simmons

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Joanna Riddoch-Contreras

Affiliation King's College London, Institute of Psychiatry, London, United Kingdom

Abdul Hye

Affiliation King's College London, Institute of Psychiatry, London, United Kingdom

Eric Westman

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Ian Pike

Affiliation Proteome Sciences plc, Cobham, Surrey, United Kingdom

Malcolm Ward

Affiliation Proteome Sciences plc, Cobham, Surrey, United Kingdom

Caroline Johnston

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Michelle Katharine Lupton

Affiliation King's College London, Institute of Psychiatry, London, United Kingdom

Katie Lunnon

Affiliation King's College London, Institute of Psychiatry, London, United Kingdom

Hilkka Soininen

Affiliation School of Neurology, University of Eastern Finland and University Hospital of Kuopio, Kuopio, Finland

Iwona Kloszewska

Affiliation Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland

Magda Tsolaki

Affiliation 3rd Department of Neurology, “G. Papanicolaou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

Bruno Vellas

Affiliation Department of Geriatric Medicine, Grontople de Toulouse, Toulouse University Hospital, Toulouse, France

Patrizia Mecocci

Affiliation Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy

Simon Lovestone

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Stephen Newhouse

Contributed equally to this work with: Stephen Newhouse, Richard Dobson

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

Richard Dobson

Contributed equally to this work with: Stephen Newhouse, Richard Dobson

steven.kiddle@kcl.ac.uk (SJK); richard.j.dobson@kcl.ac.uk (RD)

Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom

for the Alzheimers Disease Neuroimaging Initiative

Competing Interests

Intellectual property has been registered on the use of plasma proteins for use as biomarkers for AD by King's College London and Proteome Sciences, with SL and M. Thambisetty named as inventors. IP and MW were full-time employees of Proteome Sciences, London, United Kingdom, at the time of their contribution to the work described in this manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Patent Title Methods and Compositions Relating to Alzheimer's Disease Subject Covers utility of around 30 proteins, specifically listing 16 in the Dependent claims for diagnosis of Alzheimer's disease Filing Proteome Sciences with King's Business United Kingdom Priority GB0421639.6 dated 29/09/2004 PCT Application PCT/GB2005/003756 dated 29/09/2005 Application in Europe, Japan, United States, Australia, and Canada, dated 15/03/2007 to 16/10/2007. In addition Alzheimer's Disease Neuroimaging Initiative recieved funding from: Abbott; Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: M. Thambisetty AS SL SN RD. Analyzed the data: SJK. Wrote the paper: SJK M. Thambisetty AS SN RD. APOE measurements in AddNeuroMed and DCR: JRC AH IP MW MKL KL. Input on image analysis: EW. Provided cluster computing support: CJ. AddNeuroMed clinical centre lead: HS IK M. Tsolaki BV PM.