About the Authors
- Steven John Kiddle
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* E-mail: steven.kiddle@kcl.ac.uk (SJK); richard.j.dobson@kcl.ac.uk (RD)
Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Madhav Thambisetty
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Affiliation Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
- Andrew Simmons
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Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Joanna Riddoch-Contreras
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Affiliation King's College London, Institute of Psychiatry, London, United Kingdom
- Abdul Hye
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Affiliation King's College London, Institute of Psychiatry, London, United Kingdom
- Eric Westman
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Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Ian Pike
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Affiliation Proteome Sciences plc, Cobham, Surrey, United Kingdom
- Malcolm Ward
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Affiliation Proteome Sciences plc, Cobham, Surrey, United Kingdom
- Caroline Johnston
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Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Michelle Katharine Lupton
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Affiliation King's College London, Institute of Psychiatry, London, United Kingdom
- Katie Lunnon
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Affiliation King's College London, Institute of Psychiatry, London, United Kingdom
- Hilkka Soininen
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Affiliation School of Neurology, University of Eastern Finland and University Hospital of Kuopio, Kuopio, Finland
- Iwona Kloszewska
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Affiliation Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland
- Magda Tsolaki
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Affiliation 3rd Department of Neurology, “G. Papanicolaou” Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
- Bruno Vellas
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Affiliation Department of Geriatric Medicine, Grontople de Toulouse, Toulouse University Hospital, Toulouse, France
- Patrizia Mecocci
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Affiliation Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
- Simon Lovestone
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Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Stephen Newhouse
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Contributed equally to this work with: Stephen Newhouse, Richard Dobson
Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- Richard Dobson
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Contributed equally to this work with: Stephen Newhouse, Richard Dobson
* E-mail: steven.kiddle@kcl.ac.uk (SJK); richard.j.dobson@kcl.ac.uk (RD)
Affiliations National Institute of Health Research Biomedical Research Centre for Mental Health, South London and Maudsley National Health Service Foundation Trust, London, United Kingdom, King's College London, Institute of Psychiatry, London, United Kingdom
- for the Alzheimers Disease Neuroimaging Initiative
Competing Interests
Intellectual property has been registered on the use of plasma proteins for use as biomarkers for AD by King's College London and Proteome Sciences, with SL and M. Thambisetty named as inventors. IP and MW were full-time employees of Proteome Sciences, London, United Kingdom, at the time of their contribution to the work described in this manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Patent Title Methods and Compositions Relating to Alzheimer's Disease Subject Covers utility of around 30 proteins, specifically listing 16 in the Dependent claims for diagnosis of Alzheimer's disease Filing Proteome Sciences with King's Business United Kingdom Priority GB0421639.6 dated 29/09/2004 PCT Application PCT/GB2005/003756 dated 29/09/2005 Application in Europe, Japan, United States, Australia, and Canada, dated 15/03/2007 to 16/10/2007. In addition Alzheimer's Disease Neuroimaging Initiative recieved funding from: Abbott; Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: M. Thambisetty AS SL SN RD. Analyzed the data: SJK. Wrote the paper: SJK M. Thambisetty AS SN RD. APOE measurements in AddNeuroMed and DCR: JRC AH IP MW MKL KL. Input on image analysis: EW. Provided cluster computing support: CJ. AddNeuroMed clinical centre lead: HS IK M. Tsolaki BV PM.