Advertisement
Research Article

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

  • Kesavan Meganathan,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Smita Jagtap,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Vilas Wagh,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Johannes Winkler,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • John Antonydas Gaspar,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Diana Hildebrand,

    Affiliation: Institute of Clinical Chemistry, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

    X
  • Maria Trusch,

    Affiliation: Institut of Organic Chemistry, Mass Spectrometry Group, Universität Hamburg, Hamburg, Germany

    X
  • Karola Lehmann,

    Affiliation: Proteome Factory AG, Berlin, Germany

    X
  • Jürgen Hescheler,

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Hartmut Schlüter,

    Affiliation: Institute of Clinical Chemistry, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany

    X
  • Agapios Sachinidis mail

    a.sachinidis@uni-koeln.de

    Affiliation: Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany

    X
  • Published: August 28, 2012
  • DOI: 10.1371/journal.pone.0044228

About the Authors

Kesavan Meganathan, Smita Jagtap, Vilas Wagh, Johannes Winkler, John Antonydas Gaspar, Jürgen Hescheler, Agapios Sachinidis
Center of Physiology and Pathophysiology, Institute of Neurophysiology, Cologne, Germany
Diana Hildebrand, Hartmut Schlüter
Institute of Clinical Chemistry, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
Maria Trusch
Institut of Organic Chemistry, Mass Spectrometry Group, Universität Hamburg, Hamburg, Germany
Karola Lehmann
Proteome Factory AG, Berlin, Germany

Corresponding Author

Email: a.sachinidis@uni-koeln.de

Competing Interests

The authors have read the journal's policy and have the following conflicts: Karola Lehmann is employed by Proteome Factory AG. There are no other declarations relating to employment, consultancy, patents, products in development or marketed products. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials

Author Contributions

Conceived and designed the experiments: AS KM SJ VW JH HS. Performed the experiments: KM SJ VW JH HS DH MT KL. Analyzed the data: AS KM SJ JW JAG. Contributed reagents/materials/analysis tools: AS KM SJ JW JAG. Wrote the paper: AS KM.