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Research Article

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

  • D. Peter O'Leary mail,

    donaloleary@rcsi.ie

    Affiliations: Department of Academic Surgery, Cork University Hospital, Cork, Ireland, Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

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  • Lavinia Bhatt,

    Affiliation: Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

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  • John F. Woolley,

    Affiliation: Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

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  • David R. Gough,

    Affiliation: Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

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  • Jiang H. Wang,

    Affiliation: Department of Academic Surgery, Cork University Hospital, Cork, Ireland

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  • Thomas G. Cotter,

    Affiliation: Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

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  • H. Paul Redmond

    Affiliation: Department of Academic Surgery, Cork University Hospital, Cork, Ireland

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0044176

About the Authors

D. Peter O'Leary, Jiang H. Wang, H. Paul Redmond
Department of Academic Surgery, Cork University Hospital, Cork, Ireland
D. Peter O'Leary, Lavinia Bhatt, John F. Woolley, David R. Gough, Thomas G. Cotter
Tumour Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland

Corresponding Author

Email: donaloleary@rcsi.ie

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DPO JHW TGC HPR. Performed the experiments: DPO LB JFW DRG. Analyzed the data: DPO JHW TGC HPR. Contributed reagents/materials/analysis tools: TGC JHW HPR. Wrote the paper: DPO.