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Research Article

Cefditoren and Ceftriaxone Enhance Complement-Mediated Immunity in the Presence of Specific Antibodies against Antibiotic-Resistant Pneumococcal Strains

  • Elisa Ramos-Sevillano,

    Affiliation: Centro de Investigaciones Biológicas (CSIC) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain

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  • Cinthya Rodríguez-Sosa,

    Affiliation: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

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  • Fabio Cafini,

    Affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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  • Maria-Jose Giménez,

    Affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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  • Ana Navarro,

    Affiliation: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

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  • David Sevillano,

    Affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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  • Luis Alou,

    Affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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  • Ernesto García,

    Affiliation: Centro de Investigaciones Biológicas (CSIC) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain

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  • Lorenzo Aguilar,

    Affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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  • Jose Yuste mail

    jyuste@isciii.es

    Affiliations: Centro de Investigaciones Biológicas (CSIC) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain

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  • Published: September 05, 2012
  • DOI: 10.1371/journal.pone.0044135

About the Authors

Elisa Ramos-Sevillano, Ernesto García, Jose Yuste
Centro de Investigaciones Biológicas (CSIC) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain
Cinthya Rodríguez-Sosa, Ana Navarro, Jose Yuste
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain
Fabio Cafini, Maria-Jose Giménez, David Sevillano, Luis Alou, Lorenzo Aguilar
Departamento de Microbiología, Facultad de Medicina, Universidad Complutense, Madrid, Spain

Corresponding Author

Email: jyuste@isciii.es

Competing Interests

This work was supported by an unrestricted educational grant from Tedec-Meiji Farma S. A. (Madrid, Spain). Dr. Lorenzo Aguilar is a co-author of this manuscript and he is an Academic Editor for PLoS ONE.

Author Contributions

Conceived and designed the experiments: MJ-G FC DS L. Alou EG L. Aguilar JY. Performed the experiments: ER-S CR-S FC AN JY. Analyzed the data: ER-S EG L. Aguilar JY. Wrote the paper: EG L. Aguilar JY. Reviewed and approved the manuscript: ER-S CR-S FC MJ-G AN DS L. Alou EG L. Aguilar JY.