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Research Article

α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways

  • Min-Wu Chao,

    Affiliation: Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Chun-Han Chen,

    Affiliation: Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Ya-Ling Chang,

    Affiliation: Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Che-Ming Teng mail,

    apan0826@nhri.org.tw (SLP); cmteng@ntu.edu.tw (CMT)

    Affiliation: Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Shiow-Lin Pan mail

    apan0826@nhri.org.tw (SLP); cmteng@ntu.edu.tw (CMT)

    Affiliation: Department of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan

    X
  • Published: September 06, 2012
  • DOI: 10.1371/journal.pone.0044093

About the Authors

Min-Wu Chao, Chun-Han Chen, Ya-Ling Chang, Che-Ming Teng
Phamacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
Shiow-Lin Pan
Department of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MWC CHC YLC CMT SLP. Performed the experiments: MWC. Analyzed the data: MWC. Contributed reagents/materials/analysis tools: MWC CHC YLC CMT SLP. Wrote the paper: MWC SLP.