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Research Article

Involvement of AMPA Receptor GluR2 and GluR3 Trafficking in Trigeminal Spinal Subnucleus Caudalis and C1/C2 Neurons in Acute-Facial Inflammatory Pain

  • Makiko Miyamoto,

    Affiliations: Department of Anesthesiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Yoshiyuki Tsuboi,

    Affiliations: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Kuniya Honda,

    Affiliations: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Masayuki Kobayashi,

    Affiliation: Department of Pharmacology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Kogo Takamiya,

    Affiliation: Department of Medical Sciences, Section of Integrative Physiology Faculty of medicine, Graduate School of Medicine University of Miyazaki, Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki, Japan

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  • Richard L. Huganir,

    Affiliation: Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Masahiro Kondo,

    Affiliations: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Masamichi Shinoda,

    Affiliations: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Barry J. Sessle,

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Ayano Katagiri,

    Affiliation: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Daiju Kita,

    Affiliation: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Ikuko Suzuki,

    Affiliation: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Yoshiyuki Oi,

    Affiliation: Department of Anesthesiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Koichi Iwata mail

    iwata-k@dent.nihon-u.ac.jp

    Affiliations: Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan

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  • Published: August 24, 2012
  • DOI: 10.1371/journal.pone.0044055

About the Authors

Makiko Miyamoto, Yoshiyuki Oi
Department of Anesthesiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Makiko Miyamoto, Yoshiyuki Tsuboi, Kuniya Honda, Masahiro Kondo, Masamichi Shinoda, Ayano Katagiri, Daiju Kita, Ikuko Suzuki, Koichi Iwata
Department of Physiology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Yoshiyuki Tsuboi, Masahiro Kondo, Masamichi Shinoda, Koichi Iwata
Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Kuniya Honda
Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Masayuki Kobayashi
Department of Pharmacology, Nihon University School of Dentistry, Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Kogo Takamiya
Department of Medical Sciences, Section of Integrative Physiology Faculty of medicine, Graduate School of Medicine University of Miyazaki, Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki, Japan
Richard L. Huganir
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Barry J. Sessle
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: iwata-k@dent.nihon-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KI. Performed the experiments: MM YT KH M. Kobayashi M. Kondo MS DK AK IS. Analyzed the data: MM YT KH M. Kobayashi M. Kondo MS. Contributed reagents/materials/analysis tools: KH. Wrote the paper: MM KI. Contributed to discussion and reviewed/edited the manuscript: KT RLH BJS YO.