The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Ruth Thompson; Ryan Montano; Alan Eastman

doi:10.1371/journal.pone.0044021

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Open Access

Peer-reviewed

Research Article

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Ruth Thompson,

Affiliations Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Lebanon, New Hampshire, United States of America
⨯
Ryan Montano,

Affiliations Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Lebanon, New Hampshire, United States of America
⨯
Alan Eastman

* E-mail: Alan.R.Eastman@Dartmouth.edu

Affiliations Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Lebanon, New Hampshire, United States of America
⨯

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

Ruth Thompson,
Ryan Montano,
Alan Eastman

Published: August 24, 2012
https://doi.org/10.1371/journal.pone.0044021

About the Authors

Ruth Thompson

Affiliations Department of Pharmacology and Toxicology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center, Lebanon, New Hampshire, United States of America

Ryan Montano

Alan Eastman

* E-mail: Alan.R.Eastman@Dartmouth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RT AE. Performed the experiments: RT RM AE. Analyzed the data: RT AE. Wrote the paper: RT AE.

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Recombinase polymerase amplification
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DNA damage
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Phosphorylation
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DNA replication
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Cell staining
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Synthesis phase
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Nucleases
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Confocal microscopy
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