About the Authors
- Jatinder S. Sangha
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Affiliation Department of Environmental Sciences, Nova Scotia Agricultural College, Truro, Nova Scotia, Canada
- Xiaoli Sun
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Affiliations Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China
- Owen S. D. Wally
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Affiliation Department of Environmental Sciences, Nova Scotia Agricultural College, Truro, Nova Scotia, Canada
- Kaibin Zhang
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Affiliations Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
- Xiuhong Ji
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Affiliation Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada
- Zhimin Wang
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Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
- Yanwen Wang
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Affiliations Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada, Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
- Jeffrey Zidichouski
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Affiliation Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada
- Balakrishnan Prithiviraj
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* E-mail: bprithiviraj@nsac.ca (BP); Junzeng.zhang@nrc.gc.ca (JZ)
Affiliation Department of Environmental Sciences, Nova Scotia Agricultural College, Truro, Nova Scotia, Canada
- Junzeng Zhang
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* E-mail: bprithiviraj@nsac.ca (BP); Junzeng.zhang@nrc.gc.ca (JZ)
Affiliations Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, Prince Edward Island, Canada, Department of Chemistry, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
Competing Interests
B. Prithiviraj's lab was supported partially on the C. elegant model development by Acadian Seaplants Limited and the authors are grateful to Henan Wanxi Pharmaceutical Co. Ltd., Nanyang, China who provided LWDH with extracts used in this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: ZW YW J. Zidichouski BP J. Zhang. Performed the experiments: JSS XS OSDW KZ XJ. Analyzed the data: JSS XS OSDW KZ XJ. Contributed reagents/materials/analysis tools: BP J. Zhang. Wrote the paper: BP J. Zhang.