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Research Article

(-)-Epigallocatechin-3-Gallate Protects against NO-Induced Ototoxicity through the Regulation of Caspase- 1, Caspase-3, and NF-κB Activation

  • Su-Jin Kim,

    Affiliation: Department of Cosmeceutical Science, Daegu Hanny University, Kyungsan, Gyeoungbuk, Republic of Korea

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  • Jeong-Han Lee,

    Affiliation: Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea

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  • Beom-Su Kim,

    Affiliation: Wonkwang Bone Regeneration Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea

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  • Hong-Seob So,

    Affiliation: Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea

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  • Raekil Park,

    Affiliation: Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea

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  • Noh-Yil Myung,

    Affiliation: Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea

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  • Jae-Young Um equal contributor mail,

    equal contributor Contributed equally to this work with: Jae-Young Um, Seung-Heon Hong

    jyum@khu.ac.kr (JYU); jooklim@wonkwang.ac.kr (SHH)

    Affiliation: College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

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  • Seung-Heon Hong equal contributor mail

    equal contributor Contributed equally to this work with: Jae-Young Um, Seung-Heon Hong

    jyum@khu.ac.kr (JYU); jooklim@wonkwang.ac.kr (SHH)

    Affiliation: Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0043967

About the Authors

Su-Jin Kim
Department of Cosmeceutical Science, Daegu Hanny University, Kyungsan, Gyeoungbuk, Republic of Korea
Jeong-Han Lee, Hong-Seob So, Raekil Park, Noh-Yil Myung, Seung-Heon Hong
Center for Metabolic Function Regulation, Wonkwang University, Iksan, Republic of Korea
Beom-Su Kim
Wonkwang Bone Regeneration Research Institute, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
Jae-Young Um
College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJK JYU SHH. Performed the experiments: SJK BSK JHL. Analyzed the data: SJK BSK NYM JYU SHH JHL. Contributed reagents/materials/analysis tools: HSS RP JYU SHH. Wrote the paper: SJK.