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Research Article

Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice

  • Ralph Timaru-Kast,

    Affiliation: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

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  • Clara Luh,

    Affiliation: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

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  • Philipp Gotthardt,

    Affiliation: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

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  • Changsheng Huang,

    Affiliations: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany, Focus Program Translational Neuroscience, Johannes Gutenberg-University, Mainz, Germany

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  • Michael K. Schäfer,

    Affiliations: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany, Focus Program Translational Neuroscience, Johannes Gutenberg-University, Mainz, Germany

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  • Kristin Engelhard,

    Affiliation: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

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  • Serge C. Thal mail

    thal@uni-mainz.de

    Affiliations: Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany, Focus Program Translational Neuroscience, Johannes Gutenberg-University, Mainz, Germany

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pone.0043829

About the Authors

Ralph Timaru-Kast, Clara Luh, Philipp Gotthardt, Changsheng Huang, Michael K. Schäfer, Kristin Engelhard, Serge C. Thal
Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany
Changsheng Huang, Michael K. Schäfer, Serge C. Thal
Focus Program Translational Neuroscience, Johannes Gutenberg-University, Mainz, Germany

Corresponding Author

Email: thal@uni-mainz.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SCT RTK KE. Performed the experiments: RTK CL PG CH MS. Analyzed the data: RTK PG SCT CH MS. Wrote the paper: RTK SCT.