Breast Milk from Tanzanian Women Has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection In Vitro

Magdalena A. Lyimo; Matilda Ngarina Mosi; Molly L. Housman; Muhammad Zain-Ul-Abideen; Frederick V. Lee; Alexandra L. Howell; Ruth I. Connor

doi:10.1371/journal.pone.0043815

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Peer-reviewed

Research Article

Breast Milk from Tanzanian Women Has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection In Vitro

Magdalena A. Lyimo,

Current address: Department of Hematology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

Affiliations Department of Physiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Program in Experimental and Molecular Medicine, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Muhimbili National Hospital and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
⨯
Matilda Ngarina Mosi,

Current address: Department of Health Sciences, Karolinska Institute, Stockholm, Sweden

Affiliation Muhimbili National Hospital and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
⨯
Molly L. Housman,

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
⨯
Muhammad Zain-Ul-Abideen,

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
⨯
Frederick V. Lee,

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
⨯
Alexandra L. Howell,

Affiliations Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Veterans Affairs Medical Center, White River Junction, Vermont, United States of America
⨯
Ruth I. Connor

* E-mail: Ruth.I.Connor@Dartmouth.edu

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
⨯

Breast Milk from Tanzanian Women Has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection In Vitro

Magdalena A. Lyimo,
Matilda Ngarina Mosi,
Molly L. Housman,
Muhammad Zain-Ul-Abideen,
Frederick V. Lee,
Alexandra L. Howell,
Ruth I. Connor

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0043815

About the Authors

Magdalena A. Lyimo

Current address: Department of Hematology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

Affiliations Department of Physiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Program in Experimental and Molecular Medicine, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Muhimbili National Hospital and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

Matilda Ngarina Mosi

Current address: Department of Health Sciences, Karolinska Institute, Stockholm, Sweden

Affiliation Muhimbili National Hospital and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

Molly L. Housman

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Muhammad Zain-Ul-Abideen

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Frederick V. Lee

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Alexandra L. Howell

Affiliations Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Veterans Affairs Medical Center, White River Junction, Vermont, United States of America

Ruth I. Connor

* E-mail: Ruth.I.Connor@Dartmouth.edu

Affiliation Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL ALH RIC. Performed the experiments: MLH MZ FVL. Analyzed the data: MAL MLH FVL MZ ALH RIC. Contributed reagents/materials/analysis tools: MNM. Wrote the paper: MAL ALH RIC.

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Breast milk
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HIV-1
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Milk
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Breast feeding
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Cytokines
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Inflammation
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T cells
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Infants
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