About the Authors
- Abhinav Kumar
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America
- Sabine Möcklinghoff
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Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
- Fumiaki Yumoto
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Affiliations Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
- Lukasz Jaroszewski
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
- Carol L. Farr
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Anna Grzechnik
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Phuong Nguyen
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Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
- Christian X. Weichenberger
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
- Hsiu-Ju Chiu
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America
- Heath E. Klock
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
- Marc-André Elsliger
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Ashley M. Deacon
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America
- Adam Godzik
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, Center for Research in Biological Systems, University of California San Diego, La Jolla, California, United States of America
- Scott A. Lesley
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Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
- Bruce R. Conklin
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Affiliations Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America, Departments of Medicine and Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
- Robert J. Fletterick
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* E-mail: Flett@msg.UCSF.edu (RJF); wilson@scripps.edu (IAW)
Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
- Ian A. Wilson
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* E-mail: Flett@msg.UCSF.edu (RJF); wilson@scripps.edu (IAW)
Affiliations Joint Center for Structural Genomics, La Jolla, California, United States of America, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: AK SM FY LJ AMD AG SAL BRC RF IAW. Performed the experiments: AK CF FY PN CW. Analyzed the data: AK LJ CF CW AG. Wrote the paper: AK AMD FY MAE. Performed key roles in the Joint Center for Structural Genomics (JCSG) structure genomics pipeline, including bioinformatics, protein cloning and purification, crystallization, diffraction screening, and structure validation and deposition: LJ HJC CF MAE HEK. JCSG Core leaders: AMD AG SAL. Principal Investigator of the JCSG: IAW. PI and co-PI on the PSI:Biology “Structures of Protein Complexes Regulating Transcription in Embryonic Stem Cells” project, respectively: RF BRC.