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Research Article

δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

  • Gyungah Jun mail,

    gyungah@bu.edu (GJ); farrer@bu.edu (LAF)

    Affiliations: Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Juliet A. Moncaster,

    Affiliation: Department of Psychiatry, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Carolina Koutras,

    Affiliation: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

    X
  • Sudha Seshadri,

    Affiliations: Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Jacqueline Buros,

    Affiliation: Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Ann C. McKee,

    Affiliations: Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Pathology & Laboratory Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Geriatric Research Education Clinical Center, Bedford Veterans Administration Hospital, Bedford, Massachusetts, United States of America

    X
  • Georges Levesque,

    Affiliation: Neurosciences Research Centre-CHUL, Université Laval, Québec, Canada

    X
  • Philip A. Wolf,

    Affiliations: Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Peter St. George-Hyslop,

    Affiliations: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • Lee E. Goldstein,

    Affiliations: Department of Psychiatry, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Pathology & Laboratory Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Lindsay A. Farrer mail

    gyungah@bu.edu (GJ); farrer@bu.edu (LAF)

    Affiliations: Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

    X
  • Published: September 11, 2012
  • DOI: 10.1371/journal.pone.0043728

About the Authors

Gyungah Jun, Jacqueline Buros, Lindsay A. Farrer
Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Gyungah Jun, Lindsay A. Farrer
Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Gyungah Jun, Lindsay A. Farrer
Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Juliet A. Moncaster, Lee E. Goldstein
Department of Psychiatry, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Sudha Seshadri, Ann C. McKee, Philip A. Wolf, Lee E. Goldstein, Lindsay A. Farrer
Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Ann C. McKee, Lee E. Goldstein
Department of Pathology & Laboratory Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Philip A. Wolf, Lindsay A. Farrer
Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Sudha Seshadri, Philip A. Wolf
Framingham Heart Study, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Ann C. McKee, Lee E. Goldstein, Lindsay A. Farrer
Boston University Alzheimer's Disease Center, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America
Carolina Koutras, Peter St. George-Hyslop
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
Ann C. McKee
Geriatric Research Education Clinical Center, Bedford Veterans Administration Hospital, Bedford, Massachusetts, United States of America
Georges Levesque
Neurosciences Research Centre-CHUL, Université Laval, Québec, Canada
Peter St. George-Hyslop
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJ LEG PStG-H LAF. Performed the experiments: JAM CK. Analyzed the data: GJ JB LAF. Contributed reagents/materials/analysis tools: SS ACM PAW. Wrote the paper: GJ PStG-H LEG LAF. Critically evaluated and edited the manuscript for intellectual content: GJ JAM SS GL PAW PStG-H LEG LAF. Provided study supervision: PStG-H LEG LAF.