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Research Article

Synovial Fluid Progenitors Expressing CD90+ from Normal but Not Osteoarthritic Joints Undergo Chondrogenic Differentiation without Micro-Mass Culture

  • Roman J. Krawetz mail,

    rkrawetz@ucalgary.ca

    Affiliations: Department of Surgery, University of Calgary, Calgary, Alberta, Canada, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

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  • Yiru Elizabeth Wu,

    Affiliation: Department of Surgery, University of Calgary, Calgary, Alberta, Canada

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  • Liam Martin,

    Affiliation: Department of Medicine, University of Calgary, Calgary, Alberta, Canada

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  • Jerome B. Rattner,

    Affiliation: Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

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  • John R. Matyas,

    Affiliation: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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  • David A. Hart

    Affiliation: Department of Surgery, University of Calgary, Calgary, Alberta, Canada

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  • Published: August 29, 2012
  • DOI: 10.1371/journal.pone.0043616

About the Authors

Roman J. Krawetz, Yiru Elizabeth Wu, David A. Hart
Department of Surgery, University of Calgary, Calgary, Alberta, Canada
Roman J. Krawetz, Jerome B. Rattner
Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada
Liam Martin
Department of Medicine, University of Calgary, Calgary, Alberta, Canada
John R. Matyas
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

Corresponding Author

Email: rkrawetz@ucalgary.ca

Competing Interests

The authors have the following interest: This study was partly funded by Pfizer Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RJK JBR JRM DAH. Performed the experiments: RJK YEW JBR JRM. Analyzed the data: RJK. Contributed reagents/materials/analysis tools: LM JRM. Wrote the paper: RJK YEW.