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Research Article

Active Chronic Sarcoidosis is Characterized by Increased Transitional Blood B Cells, Increased IL-10-Producing Regulatory B Cells and High BAFF Levels

  • Anne Saussine,

    Affiliations: INSERM U976, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France, Service de Dermatologie, Hôpital Saint Louis, Paris, France

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  • Abdellatif Tazi,

    Affiliation: Université Paris Diderot, Sorbonne Paris Cité; AP-HP; Service de Pneumologie, Hôpital Saint Louis, Paris, France

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  • Séverine Feuillet,

    Affiliation: Université Paris Diderot, Sorbonne Paris Cité; AP-HP; Service de Pneumologie, Hôpital Saint Louis, Paris, France

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  • Michel Rybojad,

    Affiliation: Service de Dermatologie, Hôpital Saint Louis, Paris, France

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  • Caroline Juillard,

    Affiliation: Service de Dermatologie, Hôpital Saint Louis, Paris, France

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  • Anne Bergeron,

    Affiliation: Université Paris Diderot, Sorbonne Paris Cité; AP-HP; Service de Pneumologie, Hôpital Saint Louis, Paris, France

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  • Valérie Dessirier,

    Affiliations: INSERM U976, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France

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  • Fatiha Bouhidel,

    Affiliations: Service d’Anatomopathologie, Hôpital Saint Louis, Paris, France, Université Paris Diderot Sorbonne Paris Cité, Laboratory of Pahology, UMR-S 728, Paris, France

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  • Anne Janin,

    Affiliations: Service d’Anatomopathologie, Hôpital Saint Louis, Paris, France, Université Paris Diderot Sorbonne Paris Cité, Laboratory of Pahology, UMR-S 728, Paris, France

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  • Armand Bensussan mail,

    jean-david.bouaziz@sls.aphp.fr (JB); Armand.Bensussan@inserm.fr (AB)

    Affiliations: INSERM U976, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France

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  • Martine Bagot equal contributor,

    equal contributor Contributed equally to this work with: Martine Bagot, Jean-David Bouaziz

    Affiliations: INSERM U976, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France, Service de Dermatologie, Hôpital Saint Louis, Paris, France

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  • Jean-David Bouaziz equal contributor mail

    equal contributor Contributed equally to this work with: Martine Bagot, Jean-David Bouaziz

    jean-david.bouaziz@sls.aphp.fr (JB); Armand.Bensussan@inserm.fr (AB)

    Affiliations: INSERM U976, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France, Service de Dermatologie, Hôpital Saint Louis, Paris, France

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  • Published: August 22, 2012
  • DOI: 10.1371/journal.pone.0043588

About the Authors

Anne Saussine, Valérie Dessirier, Armand Bensussan, Martine Bagot, Jean-David Bouaziz
INSERM U976, Paris, France
Anne Saussine, Valérie Dessirier, Armand Bensussan, Martine Bagot, Jean-David Bouaziz
Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Immunology, Dermatology & Oncology, UMR-S 976, Paris, France
Anne Saussine, Michel Rybojad, Caroline Juillard, Martine Bagot, Jean-David Bouaziz
Service de Dermatologie, Hôpital Saint Louis, Paris, France
Abdellatif Tazi, Séverine Feuillet, Anne Bergeron
Université Paris Diderot, Sorbonne Paris Cité; AP-HP; Service de Pneumologie, Hôpital Saint Louis, Paris, France
Fatiha Bouhidel, Anne Janin
Service d’Anatomopathologie, Hôpital Saint Louis, Paris, France
Fatiha Bouhidel, Anne Janin
Université Paris Diderot Sorbonne Paris Cité, Laboratory of Pahology, UMR-S 728, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS AT VD FB AJ A. Bergeron MB JDB. Performed the experiments: AS VD FB JDB. Analyzed the data: AS AT SF RM CJ A. Bergeron VD FB AJ A. Bensussan MB JDB. Contributed reagents/materials/analysis tools: AS AT SF RM CJ A. Bergeron VD FB AJ A. Bensussan MB JDB. Wrote the paper: AS AT SF RM CJ A. Bergeron VD FB AJ A. Bensussan MB JDB.