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Research Article

Multiphoton Multispectral Fluorescence Lifetime Tomography for the Evaluation of Basal Cell Carcinomas

  • Rakesh Patalay equal contributor,

    equal contributor Contributed equally to this work with: Rakesh Patalay, Clifford Talbot, Yuriy Alexandrov

    Affiliations: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom, Department of Dermatology, Imperial College Healthcare NHS Trust, London, United Kingdom

    X
  • Clifford Talbot equal contributor,

    equal contributor Contributed equally to this work with: Rakesh Patalay, Clifford Talbot, Yuriy Alexandrov

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Yuriy Alexandrov equal contributor,

    equal contributor Contributed equally to this work with: Rakesh Patalay, Clifford Talbot, Yuriy Alexandrov

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Martin O. Lenz,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Sunil Kumar,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Sean Warren,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Ian Munro,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Mark A. A. Neil,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

    X
  • Karsten König,

    Affiliation: JenLab GmbH, Jena, Germany

    X
  • Paul M. W. French,

    Affiliation: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom

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  • Anthony Chu,

    Affiliation: Department of Dermatology, Imperial College Healthcare NHS Trust, London, United Kingdom

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  • Gordon W. H. Stamp,

    Affiliation: CRUK London Research Institute, London, United Kingdom

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  • Chris Dunsby mail

    christopher.dunsby@imperial.ac.uk

    Affiliations: Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom, Department of Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom

    X
  • Published: September 11, 2012
  • DOI: 10.1371/journal.pone.0043460

About the Authors

Rakesh Patalay, Clifford Talbot, Yuriy Alexandrov, Martin O. Lenz, Sunil Kumar, Sean Warren, Ian Munro, Mark A. A. Neil, Paul M. W. French, Chris Dunsby
Photonics Group, Department of Physics, Imperial College London, South Kensington Campus, London, United Kingdom
Rakesh Patalay, Anthony Chu
Department of Dermatology, Imperial College Healthcare NHS Trust, London, United Kingdom
Chris Dunsby
Department of Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom
Karsten König
JenLab GmbH, Jena, Germany
Gordon W. H. Stamp
CRUK London Research Institute, London, United Kingdom

Corresponding Author

Email: christopher.dunsby@imperial.ac.uk

Competing Interests

KK is the CEO of JenLab GmbH. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RP CT YA MN KK PF AC GS CD. Performed the experiments: RP CT CD. Analyzed the data: RP CT YA ML SK GS CD. Contributed reagents/materials/analysis tools: YA SW IM CD. Wrote the paper: RP CT YA SK MN KK PF AC GS CD.