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Research Article

Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

  • Simon Leuchs equal contributor,

    equal contributor Contributed equally to this work with: Simon Leuchs, Anja Saalfrank

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Anja Saalfrank equal contributor,

    equal contributor Contributed equally to this work with: Simon Leuchs, Anja Saalfrank

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Claudia Merkl,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Tatiana Flisikowska,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Marlene Edlinger,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Marina Durkovic,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Nousin Rezaei,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Mayuko Kurome,

    Affiliation: Chair of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany

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  • Valeri Zakhartchenko,

    Affiliation: Chair of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany

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  • Barbara Kessler,

    Affiliation: Chair of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany

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  • Krzysztof Flisikowski,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Alexander Kind,

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Eckhard Wolf,

    Affiliation: Chair of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany

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  • Angelika Schnieke mail

    schnieke@wzw.tum.de

    Affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0043323

About the Authors

Simon Leuchs, Anja Saalfrank, Claudia Merkl, Tatiana Flisikowska, Marlene Edlinger, Marina Durkovic, Nousin Rezaei, Krzysztof Flisikowski, Alexander Kind, Angelika Schnieke
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany
Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Eckhard Wolf
Chair of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany

Corresponding Author

Email: schnieke@wzw.tum.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL A. Saalfrank CM TF A. Schnieke. Performed the experiments: SL A. Saalfrank TF ME MD NR MK VZ BK. Analyzed the data: KF AK EW A. Schnieke. Wrote the paper: SL AK A. Schnieke.