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Research Article

Does Pet Ownership in Infancy Lead to Asthma or Allergy at School Age? Pooled Analysis of Individual Participant Data from 11 European Birth Cohorts

  • Karin C. Lødrup Carlsen equal contributor,

    equal contributor Contributed equally to this work with: Karin C. Lødrup Carlsen, Stephanie Roll

    Affiliations: Department of Paediatrics, Oslo University Hospital, Ullevål, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway

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  • Stephanie Roll equal contributor mail,

    equal contributor Contributed equally to this work with: Karin C. Lødrup Carlsen, Stephanie Roll

    stephanie.roll@charite.de

    Affiliation: Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Kai-Håkon Carlsen,

    Affiliations: Faculty of Medicine, University of Oslo, Oslo, Norway, Voksentoppen, Oslo University Hospital, Rikshospitalet, Oslo, Norway

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  • Petter Mowinckel,

    Affiliation: Department of Paediatrics, Oslo University Hospital, Ullevål, Norway

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  • Alet H. Wijga,

    Affiliation: Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

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  • Bert Brunekreef,

    Affiliations: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands

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  • Maties Torrent,

    Affiliation: Ib-salut Menorca Health Area and Fundacio Caubet-Cimera, Menorca, Spain

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  • Graham Roberts,

    Affiliation: The David Hide Asthma and Allergy Research Centre, Isle of Wight and University of Southampton, Southampton, United Kingdom

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  • S. Hasan Arshad,

    Affiliation: The David Hide Asthma and Allergy Research Centre, Isle of Wight and University of Southampton, Southampton, United Kingdom

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  • Inger Kull,

    Affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Ursula Krämer,

    Affiliation: Institut für Umweltmedizinische Forschung, University of Düsseldorf, Düsseldorf, Germany

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  • Andrea von Berg,

    Affiliation: Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany

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  • Esben Eller,

    Affiliation: Allergycenter, Department of Dermatology, Odense University Hospital, Odense, Denmark

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  • Arne Høst,

    Affiliation: Department of Pediatrics, Odense University Hospital, Odense, Denmark

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  • Claudia Kuehni,

    Affiliation: Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland

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  • Ben Spycher,

    Affiliation: Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland

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  • Jordi Sunyer,

    Affiliation: Environmental Epidemiology Research Centre and Institut Municipal d'Investigacio Medica, Barcelona, Spain

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  • Chih-Mei Chen,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany

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  • Andreas Reich,

    Affiliation: Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Anna Asarnoj,

    Affiliations: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Astrid Lindgrens' Children's Hospital, Karolinska University Hospital, Solna, Sweden

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  • Carmen Puig,

    Affiliation: Unitat recerca infancia i entorn, Institut Municipal d'Investigacio Medica - Hospital del Mar, Barcelona, Spain

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  • Olf Herbarth,

    Affiliation: Faculty of Medicine, University of Leipzig and Department of Human Exposure Research and Epidemiology, UFZ - Centre for Environmental Research Leipzig, Leipzig, Germany

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  • Jestinah M. Mahachie John,

    Affiliations: Dept. of Oto-Rhino-Laryngology, University of Ghent, Ghent, Belgium, Systems and Modeling Unit, Montefiore Institute, University of Liège, Liège, Belgium, Bioinformatics and Modeling, GIGA-R, University of Liège, Liège, Belgium

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  • Kristel Van Steen,

    Affiliations: Dept. of Oto-Rhino-Laryngology, University of Ghent, Ghent, Belgium, Systems and Modeling Unit, Montefiore Institute, University of Liège, Liège, Belgium, Bioinformatics and Modeling, GIGA-R, University of Liège, Liège, Belgium

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  • Stefan N. Willich,

    Affiliation: Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Ulrich Wahn,

    Affiliation: Dept. for Paediatric Pneumology and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Susanne Lau,

    Affiliation: Dept. for Paediatric Pneumology and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Thomas Keil, as part of the GA2LEN WP 1.5 ‘Birth Cohorts’ working group,

    Affiliation: Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Magnus Wickman

    Affiliation: Global Allergy and Asthma European Network (GA2LEN)-Work Package 1.5 ‘Birth Cohorts’

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  • Published: August 29, 2012
  • DOI: 10.1371/journal.pone.0043214

About the Authors

Karin C. Lødrup Carlsen, Petter Mowinckel
Department of Paediatrics, Oslo University Hospital, Ullevål, Norway
Karin C. Lødrup Carlsen, Kai-Håkon Carlsen
Faculty of Medicine, University of Oslo, Oslo, Norway
Stephanie Roll, Andreas Reich, Stefan N. Willich, Thomas Keil
Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany
Kai-Håkon Carlsen
Voksentoppen, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Alet H. Wijga
Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Bert Brunekreef
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
Bert Brunekreef
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Maties Torrent
Ib-salut Menorca Health Area and Fundacio Caubet-Cimera, Menorca, Spain
Graham Roberts, S. Hasan Arshad
The David Hide Asthma and Allergy Research Centre, Isle of Wight and University of Southampton, Southampton, United Kingdom
Inger Kull, Anna Asarnoj
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Ursula Krämer
Institut für Umweltmedizinische Forschung, University of Düsseldorf, Düsseldorf, Germany
Andrea von Berg
Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
Esben Eller
Allergycenter, Department of Dermatology, Odense University Hospital, Odense, Denmark
Arne Høst
Department of Pediatrics, Odense University Hospital, Odense, Denmark
Claudia Kuehni, Ben Spycher
Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland
Jordi Sunyer
Environmental Epidemiology Research Centre and Institut Municipal d'Investigacio Medica, Barcelona, Spain
Chih-Mei Chen
Institute of Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany
Anna Asarnoj
Astrid Lindgrens' Children's Hospital, Karolinska University Hospital, Solna, Sweden
Carmen Puig
Unitat recerca infancia i entorn, Institut Municipal d'Investigacio Medica - Hospital del Mar, Barcelona, Spain
Olf Herbarth
Faculty of Medicine, University of Leipzig and Department of Human Exposure Research and Epidemiology, UFZ - Centre for Environmental Research Leipzig, Leipzig, Germany
Jestinah M. Mahachie John, Kristel Van Steen
Dept. of Oto-Rhino-Laryngology, University of Ghent, Ghent, Belgium
Jestinah M. Mahachie John, Kristel Van Steen
Systems and Modeling Unit, Montefiore Institute, University of Liège, Liège, Belgium
Jestinah M. Mahachie John, Kristel Van Steen
Bioinformatics and Modeling, GIGA-R, University of Liège, Liège, Belgium
Ulrich Wahn, Susanne Lau
Dept. for Paediatric Pneumology and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
Magnus Wickman
Global Allergy and Asthma European Network (GA2LEN)-Work Package 1.5 ‘Birth Cohorts’

Corresponding Author

Email: stephanie.roll@charite.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KCLC SR SL TK. Performed the experiments: KCLC SR TK. Analyzed the data: SR AR PM JMMJ KVS. Contributed reagents/materials/analysis tools: KHC AW BB MT GR SA IK AvB EE AH CK BS JS CMC AA CP OH SW UW UK. Wrote the paper: SR KCLC TK.