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Research Article

Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing

  • Winnie S. Liang equal contributor,

    equal contributor Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • David W. Craig equal contributor,

    equal contributor Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • John Carpten equal contributor,

    equal contributor Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Mitesh J. Borad equal contributor,

    equal contributor Contributed equally to this work with: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad

    Affiliation: Mayo Clinic, Scottsdale, Arizona, United States of America

    X
  • Michael J. Demeure,

    Affiliations: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America

    X
  • Glen J. Weiss,

    Affiliations: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America

    X
  • Tyler Izatt,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Shripad Sinari,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Alexis Christoforides,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Jessica Aldrich,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Ahmet Kurdoglu,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Michael Barrett,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Lori Phillips,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Hollie Benson,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Waibhav Tembe,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Esteban Braggio,

    Affiliation: Mayo Clinic, Scottsdale, Arizona, United States of America

    X
  • Jeffrey A. Kiefer,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Christophe Legendre,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Richard Posner,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Galen H. Hostetter,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Angela Baker,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Jan B. Egan,

    Affiliations: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Mayo Clinic, Scottsdale, Arizona, United States of America

    X
  • Haiyong Han,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Douglas Lake,

    Affiliation: Arizona State University, Tempe, Arizona, United States of America

    X
  • Edward C. Stites,

    Affiliation: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America

    X
  • Ramesh K. Ramanathan,

    Affiliations: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America

    X
  • Rafael Fonseca,

    Affiliation: Mayo Clinic, Scottsdale, Arizona, United States of America

    X
  • A. Keith Stewart,

    Affiliation: Mayo Clinic, Scottsdale, Arizona, United States of America

    X
  • Daniel Von Hoff mail

    dvh@tgen.org

    Affiliations: Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, Mayo Clinic, Scottsdale, Arizona, United States of America, Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America

    X
  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0043192

About the Authors

Winnie S. Liang, David W. Craig, John Carpten, Michael J. Demeure, Glen J. Weiss, Tyler Izatt, Shripad Sinari, Alexis Christoforides, Jessica Aldrich, Ahmet Kurdoglu, Michael Barrett, Lori Phillips, Hollie Benson, Waibhav Tembe, Jeffrey A. Kiefer, Christophe Legendre, Richard Posner, Galen H. Hostetter, Angela Baker, Jan B. Egan, Haiyong Han, Edward C. Stites, Ramesh K. Ramanathan, Daniel Von Hoff
Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America
Mitesh J. Borad, Esteban Braggio, Jan B. Egan, Rafael Fonseca, A. Keith Stewart, Daniel Von Hoff
Mayo Clinic, Scottsdale, Arizona, United States of America
Michael J. Demeure, Glen J. Weiss, Ramesh K. Ramanathan, Daniel Von Hoff
Virginia G. Piper Cancer Center Clinical Trials, Scottsdale Healthcare, Scottsdale, Arizona, United States of America
Douglas Lake
Arizona State University, Tempe, Arizona, United States of America

Corresponding Author

Email: dvh@tgen.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WSL DWC JC MB MJB AKS DVH RKR RF GJW. Performed the experiments: WSL MB LP HB EB AB GHH JE. Analyzed the data: DWC TI SS AC JA AK WT CL. Contributed reagents/materials/analysis tools: RP HH DL ECS JK. Wrote the paper: WSL. Data interpretation: WSL MB JE MD GW DH JK.