About the Authors

Jonathan Howard

Affiliation Department of Neurology, Langone Medical Center, New York, New York, United States of America

Marco Battaglini

Affiliation Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy

James Scott Babb

Affiliation Department of Radiology, Langone Medical Center, New York, New York, United States of America

Donatello Arienzo

Affiliation Department of Radiology, Langone Medical Center, New York, New York, United States of America

Brigitte Holst

Affiliations Department of Radiology, Langone Medical Center, New York, New York, United States of America, Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Mirza Omari

Affiliation Department of Neurology, Langone Medical Center, New York, New York, United States of America

Nicola De Stefano

Affiliation Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy

Joseph Herbert

Affiliation Department of Neurology, Langone Medical Center, New York, New York, United States of America

Matilde Inglese

matilde.inglese@mssm.edu

Affiliations Department of Neurology, Langone Medical Center, New York, New York, United States of America, Department of Radiology, Langone Medical Center, New York, New York, United States of America, Department of Neurology Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

Nicola De Stefano serves on the scientific advisory boards for Merck Serono and Novartis; he has received funding for travel from Merck Serono, Novartis and Teva Pharmaceutical Industries ltd.; he has received speaker honoraria from Novartis, Teva Pharmaceutical lndustries ltd., Biogen-Dompé, Schering-Bayer, Sanofi-Aventis, and Merck Serono. Joseph Herbert has received grants from Biogen, Teva, Merk Serono and Bayer. Mirza Omari is funded by NIH grant R01 NS051623. Mirza Omari serves on the scientific advisory board of Celgene and she has served as consultant for Vaccinex and Biogen. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MI J. Howard ND JSB BH J. Herbert. Performed the experiments: J. Howard MB MO DA BH JSB ND J. Herbert MI. Analyzed the data: J. Howard MB MO DA BH JSB ND MI. Contributed reagents/materials/analysis tools: MB DA MO ND JSB. Wrote the paper: J. Howard ND MB BH JSB J. Herbert MI.