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Research Article

Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

  • Gustavo Arruda Bezerra equal contributor,

    equal contributor Contributed equally to this work with: Gustavo Arruda Bezerra, Elena Dobrovetsky

    Affiliation: Institute of Molecular Biosciences, University of Graz, Graz, Austria

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  • Elena Dobrovetsky equal contributor,

    equal contributor Contributed equally to this work with: Gustavo Arruda Bezerra, Elena Dobrovetsky

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Aiping Dong,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Almagul Seitova,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

    X
  • Lissete Crombett,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

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  • Lisa M. Shewchuk,

    Affiliation: GlaxoSmithKline, Computational and Structural Chemistry, North Carolina, United States of America

    X
  • Annie M. Hassell,

    Affiliation: GlaxoSmithKline, Computational and Structural Chemistry, North Carolina, United States of America

    X
  • Sharon M. Sweitzer,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

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  • Thomas D. Sweitzer,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

    X
  • Patrick J. McDevitt,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

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  • Kyung O. Johanson,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

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  • Karen M. Kennedy-Wilson,

    Affiliation: GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

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  • Doug Cossar,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

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  • Alexey Bochkarev,

    Affiliation: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

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  • Karl Gruber mail,

    karl.gruber@uni-graz.at (KG); sirano.dhepaganon@utoronto.ca (SD-P)

    Affiliation: Institute of Molecular Biosciences, University of Graz, Graz, Austria

    X
  • Sirano Dhe-Paganon mail

    karl.gruber@uni-graz.at (KG); sirano.dhepaganon@utoronto.ca (SD-P)

    Affiliations: Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, MaRS Centre, Toronto, Ontario, Canada

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  • Published: August 29, 2012
  • DOI: 10.1371/journal.pone.0043019

About the Authors

Gustavo Arruda Bezerra, Karl Gruber
Institute of Molecular Biosciences, University of Graz, Graz, Austria
Elena Dobrovetsky, Aiping Dong, Almagul Seitova, Lissete Crombett, Doug Cossar, Alexey Bochkarev, Sirano Dhe-Paganon
Structural Genomics Consortium, University of Toronto, MaRS Centre, Toronto, Ontario, Canada
Sirano Dhe-Paganon
Department of Physiology, University of Toronto, MaRS Centre, Toronto, Ontario, Canada
Lisa M. Shewchuk, Annie M. Hassell
GlaxoSmithKline, Computational and Structural Chemistry, North Carolina, United States of America
Sharon M. Sweitzer, Thomas D. Sweitzer, Patrick J. McDevitt, Kyung O. Johanson, Karen M. Kennedy-Wilson
GlaxoSmithKline, Biological Reagents and Assay Development, Collegeville, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The work was funded in part by the companies GlaxoSmithKline and Merck & Co, Inc. In addition, co-authors LMS, AMH, SMS, TDS, PJM, KOJ, and KMK-W are employees of the commercial funder GlaxoSmithKline. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GAB ED LMS SMS KOJ SD-P. Performed the experiments: GAB ED AD AS LC LMS AMH PJM KMK-W TDS. Analyzed the data: GAB ED AD LMS SMS KOJ DC AB KG SD-P. Wrote the paper: GAB AB KG SD-P.