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Research Article

Mutation in Phex Gene Predisposes BALB/c-PhexHyp-Duk/Y Mice to Otitis Media

  • Fengchan Han,

    Affiliations: The Transformative Otology and Neuroscience Center, Binzhou Medical University, Yantai, Shandong, People's Republic of China, Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Heping Yu,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Ping Li,

    Affiliation: The Transformative Otology and Neuroscience Center, Binzhou Medical University, Yantai, Shandong, People's Republic of China

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  • Jiangping Zhang,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Cong Tian,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Hongbo Li,

    Affiliation: The Transformative Otology and Neuroscience Center, Binzhou Medical University, Yantai, Shandong, People's Republic of China

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  • Qing Yin Zheng mail

    qing.Zheng@case.edu

    Affiliations: The Transformative Otology and Neuroscience Center, Binzhou Medical University, Yantai, Shandong, People's Republic of China, Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America, The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • Published: September 28, 2012
  • DOI: 10.1371/journal.pone.0043010

About the Authors

Fengchan Han, Ping Li, Hongbo Li, Qing Yin Zheng
The Transformative Otology and Neuroscience Center, Binzhou Medical University, Yantai, Shandong, People's Republic of China
Fengchan Han, Heping Yu, Jiangping Zhang, Cong Tian, Qing Yin Zheng
Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, United States of America
Qing Yin Zheng
The Jackson Laboratory, Bar Harbor, Maine, United States of America

Corresponding Author

Email: qing.Zheng@case.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QYZ FH. Performed the experiments: FH HY PL JZ CT HL QYZ. Analyzed the data: FH HY PL JZ CT HL QYZ. Contributed reagents/materials/analysis tools: FH QYZ. Wrote the paper: FH JZ QYZ.