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Research Article

Low Bone Turnover and Low BMD in Down Syndrome: Effect of Intermittent PTH Treatment

  • Tristan W. Fowler equal contributor,

    equal contributor Contributed equally to this work with: Tristan W. Fowler, Kent D. McKelvey

    Affiliations: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Kent D. McKelvey equal contributor,

    equal contributor Contributed equally to this work with: Tristan W. Fowler, Kent D. McKelvey

    Affiliation: Department of Genetics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Nisreen S. Akel,

    Affiliations: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Jaclyn Vander Schilden,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Anthony W. Bacon,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • John W. Bracey,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Timothy Sowder,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Robert A. Skinner,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Frances L. Swain,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • William R. Hogue,

    Affiliation: Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Donna B. Leblanc,

    Affiliation: Department of Genetics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Dana Gaddy,

    Affiliations: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Galen R. Wenger,

    Affiliation: Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Larry J. Suva mail

    suvalarryj@uams.edu

    Affiliations: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Published: August 14, 2012
  • DOI: 10.1371/journal.pone.0042967

About the Authors

Tristan W. Fowler, Nisreen S. Akel, Dana Gaddy, Larry J. Suva
Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Tristan W. Fowler, Nisreen S. Akel, Jaclyn Vander Schilden, Anthony W. Bacon, John W. Bracey, Timothy Sowder, Robert A. Skinner, Frances L. Swain, William R. Hogue, Dana Gaddy, Larry J. Suva
Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Kent D. McKelvey, Donna B. Leblanc
Department of Genetics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Galen R. Wenger
Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Corresponding Author

Email: suvalarryj@uams.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KDM LJS GRW DG. Performed the experiments: TWF NSA JVS AWB JWB TS RAS FLS DBL WRH. Analyzed the data: LJS DG NSA TWF. Contributed reagents/materials/analysis tools: KDM DBL. Wrote the paper: LJS DG GAW KDM TWF.