About the Authors

Beat Nyfeler

Contributed equally to this work with: Beat Nyfeler, Dominic Hoepfner

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Dominic Hoepfner

Contributed equally to this work with: Beat Nyfeler, Dominic Hoepfner

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

Deborah Palestrant

Affiliation Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Christina A. Kirby

Affiliation Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Lewis Whitehead

Affiliation Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachussetts, United States of America

Robert Yu

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Gejing Deng

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Ruth E. Caughlan

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Angela L. Woods

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Adriana K. Jones

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

S. Whitney Barnes

Affiliation Novartis Institute for Functional Genomics, Novartis Institutes for Biomedical Research, San Diego, California, United States of America

John R. Walker

Affiliation Novartis Institute for Functional Genomics, Novartis Institutes for Biomedical Research, San Diego, California, United States of America

Swann Gaulis

Affiliation Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland

Ervan Hauy

Affiliation Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland

Saskia M. Brachmann

Affiliation Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland

Philipp Krastel

Affiliation Center for Proteomic Chemistry, Natural Products Unit, Novartis Institutes for BioMedical Research, Basel, Switzerland

Christian Studer

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

Ralph Riedl

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

David Estoppey

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

Thomas Aust

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

N. Rao Movva

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland

Zuncai Wang

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Michael Salcius

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Gregory A. Michaud

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Gregory McAllister

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Leon O. Murphy

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

John A. Tallarico

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Christopher J. Wilson

Affiliation Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachussetts, United States of America

Charles R. Dean

charlesr.dean@novartis.com

Affiliation Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Competing Interests

The authors are, at present, or were during the time of their contribution to this manuscript, employed by Novartis Pharmaceuticals, under the umbrella of the Novartis Institutes for Biomedical Research (NIBR). As such, the authors all own stock in Novartis as part of their remuneration for employment. There are no competing interests as regards consultancies, patents or products in development or currently marketed. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CRD BN DH DP CK GD. Performed the experiments: REC ALW AKJ SWB RY CS RR TA DE BN ZW MS EH. Analyzed the data: CRD BN DH SWB LW JRW GAM GM LOM CJW SG SMB JT NRM. Contributed reagents/materials/analysis tools: PK. Wrote the paper: CD BN DH CK.