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Research Article

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

  • Eleonora Napoli,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Catherine Ross-Inta,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Sarah Wong,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Connie Hung,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Yasuko Fujisawa,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Danielle Sakaguchi,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • James Angelastro,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Alicja Omanska-Klusek,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Robert Schoenfeld,

    Affiliation: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

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  • Cecilia Giulivi mail

    cgiulivi@ucdavis.edu

    Affiliations: Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America, Medical Investigations of Neurodevelopmental Disorders Institute, School of Medicine, University of California Davis, Davis, California, United States of America

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  • Published: August 10, 2012
  • DOI: 10.1371/journal.pone.0042504

About the Authors

Eleonora Napoli, Catherine Ross-Inta, Sarah Wong, Connie Hung, Yasuko Fujisawa, Danielle Sakaguchi, James Angelastro, Alicja Omanska-Klusek, Robert Schoenfeld, Cecilia Giulivi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
Cecilia Giulivi
Medical Investigations of Neurodevelopmental Disorders Institute, School of Medicine, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: cgiulivi@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EN YF CG. Performed the experiments: EN CRI DS SW CH RS YF AOK. Analyzed the data: EN CRI SW CH YF CG. Wrote the paper: EN CRI SW JA CG. Obtained permission to use cell line: CG.