About the Authors

Shravan Madireddi

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Rich-Henry Schabowsky

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Abhishek K. Srivastava

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Rajesh K. Sharma

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Esma S. Yolcu

Contributed equally to this work with: Esma S. Yolcu, Haval Shirwan

haval.shirwan@louisville.edu (HS); esma.yolcu@louisville.edu (ESY)

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Haval Shirwan

Contributed equally to this work with: Esma S. Yolcu, Haval Shirwan

haval.shirwan@louisville.edu (HS); esma.yolcu@louisville.edu (ESY)

Affiliation Institute for Cellular Therapeutics, Department of Microbiology and Immunology, and James Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

Competing Interests

The authors have read the journal’s policy and have the following conflicts: The SA-4-1BBL protein described in this manuscript is licensed from University of Louisville by ApoVax, Inc., Louisville, KY, for which HS serves as the Member of the Board and CSO, and HS and ESY have significant equity interest in the Company. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SM ESY HS. Performed the experiments: SM R-HS AKS RKS ESY. Analyzed the data: SM R-HS AKS RKS ESY HS. Wrote the paper: SM R-HS RKS ESY HS.