About the Authors
- Romina Nassini
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Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto
Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
- Pamela Pedretti
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Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto
Affiliations Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy, Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Nadia Moretto
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Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto
Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Camilla Fusi
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Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
- Chiara Carnini
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Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Fabrizio Facchinetti
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Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Arturo Roberto Viscomi
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Affiliation Department of Biochemistry and Molecular Biology, University of Parma, Italy
- Anna Rita Pisano
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Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Susan Stokesberry
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Affiliation Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom
- Charlott Brunmark
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Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Truly Translational Sweden AB, Lund, Sweden
- Naila Svitacheva
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Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Disease Pharmacology LEO Pharma A/S, Ballerup, Denmark
- Lorcan McGarvey
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Affiliation Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom
- Riccardo Patacchini
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Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy
- Anders B. Damholt
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Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Department of Biology, University of Copenhagen, Copenhagen, Denmark
- Pierangelo Geppetti
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* E-mail: geppetti@unifi.it
Affiliations Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy, Headache Center, University of Florence, Florence, Italy
- Serena Materazzi
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Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Competing Interests
CB, NS and ABD at the time when the study was performed were employees of AstraZeneca. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Currently, CB and NS are employees at Truly Translational Sweden AB, and LEO Pharma A/S, respectively, while ABD is an employee of the University of Copenhagen. PP, NM, CC, FF, ARP, RP are currently employees at Chiesi Farmaceutici SpA. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: RN RP ABD PG SM. Performed the experiments: RN PP NM CF ARV ARP SS CB NS SM. Analyzed the data: RN PP NM CC CB SM. Contributed reagents/materials/analysis tools: CC ARV SS. Wrote the paper: RN FF LMG RP ABD PG SM.