About the Authors

Romina Nassini

Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto

Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

Pamela Pedretti

Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto

Affiliations Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy, Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Nadia Moretto

Contributed equally to this work with: Romina Nassini, Pamela Pedretti, Nadia Moretto

Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Camilla Fusi

Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

Chiara Carnini

Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Fabrizio Facchinetti

Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Arturo Roberto Viscomi

Affiliation Department of Biochemistry and Molecular Biology, University of Parma, Italy

Anna Rita Pisano

Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Susan Stokesberry

Affiliation Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom

Charlott Brunmark

Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Truly Translational Sweden AB, Lund, Sweden

Naila Svitacheva

Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Disease Pharmacology LEO Pharma A/S, Ballerup, Denmark

Lorcan McGarvey

Affiliation Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom

Riccardo Patacchini

Affiliation Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy

Anders B. Damholt

Affiliations AstraZeneca Research & Development Innovative Medicines Respiratory & Inflammation, Mölndal, Sweden, Department of Biology, University of Copenhagen, Copenhagen, Denmark

Pierangelo Geppetti

geppetti@unifi.it

Affiliations Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy, Headache Center, University of Florence, Florence, Italy

Serena Materazzi

Affiliation Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy

Competing Interests

CB, NS and ABD at the time when the study was performed were employees of AstraZeneca. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Currently, CB and NS are employees at Truly Translational Sweden AB, and LEO Pharma A/S, respectively, while ABD is an employee of the University of Copenhagen. PP, NM, CC, FF, ARP, RP are currently employees at Chiesi Farmaceutici SpA. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RN RP ABD PG SM. Performed the experiments: RN PP NM CF ARV ARP SS CB NS SM. Analyzed the data: RN PP NM CC CB SM. Contributed reagents/materials/analysis tools: CC ARV SS. Wrote the paper: RN FF LMG RP ABD PG SM.