About the Authors

Timothy Gatheral

Affiliation Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, United Kingdom

Daniel M. Reed

Affiliation Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, United Kingdom

Laura Moreno

Affiliations Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, United Kingdom, Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

Peter J. Gough

Affiliation Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Philadelphia, Pennsylvania, United States of America

Bart J. Votta

Affiliation Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Philadelphia, Pennsylvania, United States of America

Clark A. Sehon

Affiliation Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Philadelphia, Pennsylvania, United States of America

David J. Rickard

Affiliation Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Philadelphia, Pennsylvania, United States of America

John Bertin

Affiliation Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Philadelphia, Pennsylvania, United States of America

Eric Lim

Affiliations Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom, National Heart and Lung Institute, Imperial College, London, United Kingdom

Andrew G. Nicholson

Affiliations Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom, National Heart and Lung Institute, Imperial College, London, United Kingdom

Jane A. Mitchell

j.a.mitchell@ic.ac.uk

Affiliations Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, United Kingdom, Institute of Cardiovascular Medicine and Science (ICMS), London, United Kingdom

Competing Interests

The authors have read the journal’s policy and have the following conflicts: Timothy Gatheral has received honoraria from GlaxoSmithKline for participation in educational meetings regarding the management of asthma and COPD. Peter Gough, Bart Votta and John Bertin are all paid employees of GlaxoSmithKline. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TG DMR LM PG BV CS DJR JB EL AN JM. Performed the experiments: TG DR . Analyzed the data: TG DMR LM PG BV CS DJR JB JM. Contributed reagents/materials/analysis tools: PG BV CS DJR JB EL AN. Wrote the paper: TG DMR JM.