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Research Article

Depressive Symptoms and Cortisol Rhythmicity Predict Survival in Patients with Renal Cell Carcinoma: Role of Inflammatory Signaling

  • Lorenzo Cohen mail,

    lcohen@mdanderson.org

    Affiliation: Department of General Oncology and the Integrative Medicine Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Steven W. Cole,

    Affiliation: Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America

    X
  • Anil K. Sood,

    Affiliation: Department of Gynecologic Oncology and Cancer Biology Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Sarah Prinsloo,

    Affiliation: Department of General Oncology and the Integrative Medicine Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Clemens Kirschbaum,

    Affiliation: Technical University of Dresden, Dresden, Germany

    X
  • Jesusa M. G. Arevalo,

    Affiliation: Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America

    X
  • Nicholas B. Jennings,

    Affiliation: Department of Gynecologic Oncology and Cancer Biology Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Shellie Scott,

    Affiliation: Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Luis Vence,

    Affiliation: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Qi Wei,

    Affiliation: Department of General Oncology and the Integrative Medicine Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Diane Kentor,

    Affiliation: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Laszlo Radvanyi,

    Affiliation: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Nizar Tannir,

    Affiliation: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Eric Jonasch,

    Affiliation: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Pheroze Tamboli,

    Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Louis Pisters

    Affiliation: Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Published: August 01, 2012
  • DOI: 10.1371/journal.pone.0042324

About the Authors

Lorenzo Cohen, Sarah Prinsloo, Qi Wei
Department of General Oncology and the Integrative Medicine Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Steven W. Cole, Jesusa M. G. Arevalo
Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
Anil K. Sood, Nicholas B. Jennings
Department of Gynecologic Oncology and Cancer Biology Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Clemens Kirschbaum
Technical University of Dresden, Dresden, Germany
Shellie Scott, Louis Pisters
Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Luis Vence, Diane Kentor, Laszlo Radvanyi
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Nizar Tannir, Eric Jonasch
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Pheroze Tamboli
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Corresponding Author

Email: lcohen@mdanderson.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LC SS LP SC AS. Performed the experiments: SC AS CK JA NJ LV DK LC PT. Analyzed the data: LC SC AS SP QW NT EJ LP. Contributed reagents/materials/analysis tools: NT EJ LP LC SS PT. Wrote the paper: LC SC AS SP QW NT EJ LP. Financial support: LC SC AS LR. Collection and assembly of data: LC SC AS CK JA NJ SS LV DK LR LP. Final approval of manuscript: LC SC AS SP QW NT EJ LP.