Acute Doxorubicin Insult in the Mouse Ovary Is Cell- and Follicle-Type Dependent

Elon C. Roti Roti; Scott K. Leisman; David H. Abbott; Sana M. Salih

doi:10.1371/journal.pone.0042293

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Peer-reviewed

Research Article

Acute Doxorubicin Insult in the Mouse Ovary Is Cell- and Follicle-Type Dependent

Elon C. Roti Roti,

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America
⨯
Scott K. Leisman,

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America
⨯
David H. Abbott,

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America
⨯
Sana M. Salih

* E-mail: salih@wisc.edu

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America
⨯

Acute Doxorubicin Insult in the Mouse Ovary Is Cell- and Follicle-Type Dependent

Elon C. Roti Roti,
Scott K. Leisman,
David H. Abbott,
Sana M. Salih

Published: August 2, 2012
https://doi.org/10.1371/journal.pone.0042293

About the Authors

Elon C. Roti Roti

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America

Scott K. Leisman

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America

David H. Abbott

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America

Sana M. Salih

* E-mail: salih@wisc.edu

Affiliation University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility Division, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ECRR DHA SMS. Performed the experiments: ECRR SKL. Analyzed the data: ECRR SKL DHA SMS. Wrote the paper: ECRR. Scientifically edited manuscript: SMS DHA.

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Ovaries
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Granulosa cells
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Apoptosis
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DNA damage
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Oocytes
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Fluorescence imaging
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Chemotherapy
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Chemotherapeutic agents
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