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Research Article

A Longitudinal Trial Comparing Chloroquine as Monotherapy or in Combination with Artesunate, Azithromycin or Atovaquone-Proguanil to Treat Malaria

  • Miriam K. Laufer mail,

    mlaufer@medicine.umaryland.edu

    Affiliation: Malaria Group, Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Phillip C. Thesing,

    Affiliation: Malaria Group, Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Fraction K. Dzinjalamala,

    Affiliation: Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

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  • Osward M. Nyirenda,

    Affiliation: Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

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  • Rhoda Masonga,

    Affiliation: Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

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  • Matthew B. Laurens,

    Affiliation: Malaria Group, Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Abbie Stokes-Riner,

    Affiliation: EMMES Corporation, Rockville, Maryland, United States of America

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  • Terrie E. Taylor,

    Affiliation: College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America

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  • Christopher V. Plowe

    Affiliation: Malaria Group, Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Published: August 17, 2012
  • DOI: 10.1371/journal.pone.0042284

About the Authors

Miriam K. Laufer, Phillip C. Thesing, Matthew B. Laurens, Christopher V. Plowe
Malaria Group, Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Fraction K. Dzinjalamala, Osward M. Nyirenda, Rhoda Masonga
Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi
Abbie Stokes-Riner
EMMES Corporation, Rockville, Maryland, United States of America
Terrie E. Taylor
College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America

Corresponding Author

Email: mlaufer@medicine.umaryland.edu

Competing Interests

MKL received an investigator-initiate grant from Pfizer Global Pharmaceuticals from 2006–2010. Azithromycin was donated by Pfizer, Inc.. ASR is employed by EMMES Corporation. There are no patents, products in development or further marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MKL FKD PCT TET CVP. Performed the experiments: MKL PCT FKD OMN RM MBL TET. Analyzed the data: MKL ASR CVP. Wrote the paper: MKL ASR TET CVP.