About the Authors

Aaron Petty

Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin

Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Eugene Myshkin

Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin

Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Haina Qin

Contributed equally to this work with: Aaron Petty, Eugene Myshkin, Haina Qin

Affiliation Departments of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore

Hong Guo

Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Hui Miao

Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Gregory P. Tochtrop

Affiliations Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Jer-Tsong Hsieh

Affiliation Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Phillip Page

Affiliation Reichert, Inc., Depew, New York, United States of America

Lili Liu

Affiliation Department of Medicine, Division of Hematology and Oncology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Daniel J. Lindner

Affiliation Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

Chayan Acharya

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America

Alexander D. MacKerell Jr

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America

Eckhard Ficker

Affiliation Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Jianxing Song

bchsj@nus.edu.sg (JS); bxw14@case.edu (BW)

Affiliations Departments of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Bingcheng Wang

bchsj@nus.edu.sg (JS); bxw14@case.edu (BW)

Affiliations Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Competing Interests

Dr. P. Page is employed by Reichert, Inc. Binding analysis was carried out using standard biosensor chips and the SR7000DC Dual Channel SPR System, a product of Reichert Life Sciences. There are no other patents, products in development or other marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AP EM BW. Performed the experiments: AP EM HQ HM HG PP. Analyzed the data: AP EM HQ PP CA ADM BW. Contributed reagents/materials/analysis tools: GT EF J-TH DL LL ADM. Wrote the paper: AP EM JS BW.