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Research Article

Bacterial Community Shift in Treated Periodontitis Patients Revealed by Ion Torrent 16S rRNA Gene Amplicon Sequencing

  • Sebastian Jünemann mail,

    jueneman@cebitec.uni-bielefeld.de

    Affiliations: Department for Periodontology, University of Münster, Münster, Germany, Institute for Bioinformatics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany

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  • Karola Prior,

    Affiliation: Department for Periodontology, University of Münster, Münster, Germany

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  • Rafael Szczepanowski,

    Affiliation: Department for Periodontology, University of Münster, Münster, Germany

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  • Inga Harks,

    Affiliation: Department for Periodontology, University of Münster, Münster, Germany

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  • Benjamin Ehmke,

    Affiliation: Department for Periodontology, University of Münster, Münster, Germany

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  • Alexander Goesmann,

    Affiliations: Institute for Bioinformatics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany, Bioinformatics Resource Facility, Center for Biotechnology, Bielefeld University, Bielefeld, Germany

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  • Jens Stoye,

    Affiliations: Institute for Bioinformatics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany, Genome Informatics Group, Faculty of Technology, Bielefeld University, Bielefeld, Germany

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  • Dag Harmsen

    Affiliation: Department for Periodontology, University of Münster, Münster, Germany

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  • Published: August 01, 2012
  • DOI: 10.1371/journal.pone.0041606

About the Authors

Sebastian Jünemann, Karola Prior, Rafael Szczepanowski, Inga Harks, Benjamin Ehmke, Dag Harmsen
Department for Periodontology, University of Münster, Münster, Germany
Sebastian Jünemann, Alexander Goesmann, Jens Stoye
Institute for Bioinformatics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany
Alexander Goesmann
Bioinformatics Resource Facility, Center for Biotechnology, Bielefeld University, Bielefeld, Germany
Jens Stoye
Genome Informatics Group, Faculty of Technology, Bielefeld University, Bielefeld, Germany

Corresponding Author

Email: jueneman@cebitec.uni-bielefeld.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed this study: DH. Conceived and designed clinical trial: BE DH. Performed clinical trial: BE IH. Performed Ion Torrent sequencing and real-time PCR: KP RS. Conceived and designed bioinformatic analysis: SJ AG JS. Performed bioinformatic analysis: SJ. First draft of manuscript: SJ DH KP. Contributed and approved the final version of the manuscript: SJ KP RS IH BE AG JS DH.