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Research Article

Deep Panning: Steps towards Probing the IgOme

  • Arie Ryvkin equal contributor,

    equal contributor Contributed equally to this work with: Arie Ryvkin, Haim Ashkenazy

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Haim Ashkenazy equal contributor,

    equal contributor Contributed equally to this work with: Arie Ryvkin, Haim Ashkenazy

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Larisa Smelyanski,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Gilad Kaplan,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Osnat Penn,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Yael Weiss-Ottolenghi,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Eyal Privman,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

    Current address: Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

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  • Peter B. Ngam,

    Affiliation: National Center for Genome Resources, Santa Fe, New Mexico, United States of America

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  • James E. Woodward,

    Affiliation: National Center for Genome Resources, Santa Fe, New Mexico, United States of America

    Current address: Department of Plant Pathology, University of California Davis, Davis, California, United States of America

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  • Gregory D. May,

    Affiliation: National Center for Genome Resources, Santa Fe, New Mexico, United States of America

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  • Callum Bell,

    Affiliation: National Center for Genome Resources, Santa Fe, New Mexico, United States of America

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  • Tal Pupko,

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Jonathan M. Gershoni mail

    gershoni@tauex.tau.ac.il

    Affiliation: Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel

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  • Published: August 01, 2012
  • DOI: 10.1371/journal.pone.0041469

About the Authors

Arie Ryvkin, Haim Ashkenazy, Larisa Smelyanski, Gilad Kaplan, Osnat Penn, Yael Weiss-Ottolenghi, Eyal Privman, Tal Pupko, Jonathan M. Gershoni
Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel
Peter B. Ngam, James E. Woodward, Gregory D. May, Callum Bell
National Center for Genome Resources, Santa Fe, New Mexico, United States of America

Corresponding Author

Email: gershoni@tauex.tau.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: AR HA JMG. Wrote the paper: JMG. Conceived the project: JMG. Designed the experiments: AR HA JMG. Performed bioinformatical computations: HA OP EP AR TP. Constructed the fth1-dp phage vector and naïve libraries: LS. Performed the bio-panning: LS GK YW. Conducted deep sequencing: GDM PN CB JEW. Contributed sequencing devices: GDM PN CB JEW. Reviewed and edited the manuscript: AR HA LS GK OP YW EP PN JEW GDM CB TP JMG.