About the Authors

Kathryn J. Huber-Keener

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Xiuping Liu

Affiliation Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, United States of America

Zhong Wang

Affiliation The Center for Statistical Genetics, The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Yaqun Wang

Affiliation The Center for Statistical Genetics, The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Willard Freeman

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Song Wu

Affiliation Department of Applied Mathematics and Statistics, State University of New York, Stony Brook, New York, United States of America

Maricarmen D. Planas-Silva

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Xingcong Ren

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Yan Cheng

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Yi Zhang

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Kent Vrana

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Chang-Gong Liu

cgliu@mdanderson.org (CL); juy16@psu.edu (JY); or rwu@hes.hmc.psu.edu (RW)

Affiliation Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, United States of America

Jin-Ming Yang

cgliu@mdanderson.org (CL); juy16@psu.edu (JY); or rwu@hes.hmc.psu.edu (RW)

Affiliation Department of Pharmacology, The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Rongling Wu

cgliu@mdanderson.org (CL); juy16@psu.edu (JY); or rwu@hes.hmc.psu.edu (RW)

Affiliation The Center for Statistical Genetics, The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJH CGL RW JMY. Performed the experiments: KJH XL XR YC YZ. Analyzed the data: KJH ZW WF YW SW RW. Contributed reagents/materials/analysis tools: WF MDP KV. Wrote the paper: KJH WF KV RW JMY. Created analysis model: ZW YW SW RW.