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Research Article

RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells

  • Devin T. Rosenthal,

    Affiliations: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, United States of America

    Current address: Department of Anatomy, Tufts University, Boston, Massachusetts, United States of America

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  • Jie Zhang,

    Affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Liwei Bao,

    Affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Lian Zhu,

    Affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Zhifen Wu,

    Affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Kathy Toy,

    Affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Celina G. Kleer,

    Affiliations: Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Sofia D. Merajver mail

    smerajve@med.umich.edu

    Affiliations: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, United States of America, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: July 23, 2012
  • DOI: 10.1371/journal.pone.0040979

About the Authors

Devin T. Rosenthal, Jie Zhang, Liwei Bao, Lian Zhu, Zhifen Wu, Sofia D. Merajver
Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
Devin T. Rosenthal, Celina G. Kleer, Sofia D. Merajver
Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, United States of America
Kathy Toy, Celina G. Kleer
Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America
Celina G. Kleer, Sofia D. Merajver
University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: smerajve@med.umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DTR JZ SDM. Performed the experiments: DTR JZ LB LZ ZW KT. Analyzed the data: DTR JZ LB LZ ZW KT CGK SDM. Contributed reagents/materials/analysis tools: CGK SDM. Wrote the paper: DTR SDM.