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Research Article

Gene Expression Profiling Identifies HOXB4 as a Direct Downstream Target of GATA-2 in Human CD34+ Hematopoietic Cells

  • Tohru Fujiwara,

    Affiliations: Molecular Hematology/Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan, Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Hisayuki Yokoyama,

    Affiliations: Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, Department of Hematology, Sendai Medical Center, Sendai, Japan

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  • Yoko Okitsu,

    Affiliation: Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Mayumi Kamata,

    Affiliation: Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Noriko Fukuhara,

    Affiliation: Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Yasushi Onishi,

    Affiliation: Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Shinichi Fujimaki,

    Affiliation: Infection Control and Laboratory Diagnosis, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Shinichiro Takahashi,

    Affiliation: Division of Hematology, Kitasato University School of Allied Health Sciences, Sagamihara, Japan

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  • Kenichi Ishizawa,

    Affiliation: Molecular Hematology/Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Emery H. Bresnick,

    Affiliation: Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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  • Hideo Harigae mail

    harigae@med.tohoku.ac.jp

    Affiliations: Molecular Hematology/Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan, Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

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  • Published: September 24, 2012
  • DOI: 10.1371/journal.pone.0040959

About the Authors

Tohru Fujiwara, Kenichi Ishizawa, Hideo Harigae
Molecular Hematology/Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
Tohru Fujiwara, Hisayuki Yokoyama, Yoko Okitsu, Mayumi Kamata, Noriko Fukuhara, Yasushi Onishi, Hideo Harigae
Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Hisayuki Yokoyama
Department of Hematology, Sendai Medical Center, Sendai, Japan
Shinichi Fujimaki
Infection Control and Laboratory Diagnosis, Tohoku University Graduate School of Medicine, Sendai, Japan
Shinichiro Takahashi
Division of Hematology, Kitasato University School of Allied Health Sciences, Sagamihara, Japan
Emery H. Bresnick
Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Corresponding Author

Email: harigae@med.tohoku.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TF HY HH. Performed the experiments: TF HY Y. Okitsu MK SF. Analyzed the data: TF HY. Contributed reagents/materials/analysis tools: Y. Onishi NF KI HH. Wrote the paper: TF HY ST EHB HH.