About the Authors
- Teri L. Kissner
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Gordon Ruthel
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Shahabuddin Alam
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Enrique Mann
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Affiliation Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Dariush Ajami
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Affiliation Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Mitra Rebek
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Affiliation Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Eileen Larkin
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Stefan Fernandez
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Robert G. Ulrich
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Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Sun Ping
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Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
- David S. Waugh
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Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
- Julius Rebek Jr
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Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
- Kamal U. Saikh
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* E-mail: kamal.saikh@amedd.army.mil
Affiliation Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: Performed cytokine measurement and micro-array experiments: TLK. Partly involved in writing the manuscript: TLK. Performed the confocal image data collection and edited the manuscript: GR. Performed the transfection, co-immunoprecipitation and animal experiments: SA. Contributed in the synthesis of compounds: EM DA. Contributed optimization and data analysis of micro-array based binding experiments: EL SF RU. Contributed design and synthesis of BB-loop mimetic: MR. Contributed expression and purification of TIR domain recombinant protein: SP DSW. Designed and supervised overall synthetic chemistry: JR. Designed and supervised the research and wrote the manuscript: KUS. Performed the experiments: TLK GR SA EM DA EL SF SP KUS. Analyzed the data: TLK GR SA EM DA MR EL SF SP DSW JR KUS. Contributed reagents/materials/analysis tools: RGU. Wrote the paper: TLK SP MR KUS.