About the Authors
- Teri L. Kissner, Gordon Ruthel, Shahabuddin Alam, Eileen Larkin, Stefan Fernandez, Robert G. Ulrich, Kamal U. Saikh
- Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
- Enrique Mann, Dariush Ajami, Mitra Rebek
- Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Sun Ping, David S. Waugh, Julius Rebek Jr
- Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
The authors have declared that no competing interests exist.
Conceived and designed the experiments: Performed cytokine measurement and micro-array experiments: TLK. Partly involved in writing the manuscript: TLK. Performed the confocal image data collection and edited the manuscript: GR. Performed the transfection, co-immunoprecipitation and animal experiments: SA. Contributed in the synthesis of compounds: EM DA. Contributed optimization and data analysis of micro-array based binding experiments: EL SF RU. Contributed design and synthesis of BB-loop mimetic: MR. Contributed expression and purification of TIR domain recombinant protein: SP DSW. Designed and supervised overall synthetic chemistry: JR. Designed and supervised the research and wrote the manuscript: KUS. Performed the experiments: TLK GR SA EM DA EL SF SP KUS. Analyzed the data: TLK GR SA EM DA MR EL SF SP DSW JR KUS. Contributed reagents/materials/analysis tools: RGU. Wrote the paper: TLK SP MR KUS.