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Research Article

Early Brain Vulnerability in Wolfram Syndrome

  • Tamara Hershey mail,

    tammy@npg.wustl.edu

    Affiliations: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Heather M. Lugar,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Joshua S. Shimony,

    Affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jerrel Rutlin,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jonathan M. Koller,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Dana C. Perantie,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Alex R. Paciorkowski,

    Affiliation: Department of Neurology, University of Washington, St. Louis, Missouri, United States of America

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  • Sarah A. Eisenstein,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • M. Alan Permutt,

    Affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • the Washington University Wolfram Study Group

    Members of The Washington University Wolfram Study Group are listed in the Acknowledgments section.

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  • Published: July 11, 2012
  • DOI: 10.1371/journal.pone.0040604

About the Authors

Tamara Hershey, Heather M. Lugar, Jerrel Rutlin, Jonathan M. Koller, Dana C. Perantie, Sarah A. Eisenstein
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America
Tamara Hershey
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Tamara Hershey, Joshua S. Shimony
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
M. Alan Permutt
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
Alex R. Paciorkowski
Department of Neurology, University of Washington, St. Louis, Missouri, United States of America

Corresponding Author

Email: tammy@npg.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TH MAP. Performed the experiments: AP HL DP. Analyzed the data: JS HL JK SE JR TH. Wrote the paper: TH HL.