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Research Article

Structural Differences between Human Proteins and Aero- and Microbial Allergens Define Allergenicity

  • Helton da Costa Santiago,

    Affiliation: The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sasisekhar Bennuru,

    Affiliation: The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • José M. C. Ribeiro,

    Affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Thomas B. Nutman mail

    tnutman@niaid.nih.gov

    Affiliation: The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil

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  • Published: July 18, 2012
  • DOI: 10.1371/journal.pone.0040552

About the Authors

Helton da Costa Santiago, Sasisekhar Bennuru, Thomas B. Nutman
The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
José M. C. Ribeiro
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

Corresponding Author

Email: tnutman@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HCS SB JMCR TN. Performed the experiments: HCS SB. Analyzed the data: HCS SB JMCR TN. Contributed reagents/materials/analysis tools: HCS JMCR TN. Wrote the paper: HCS TN.