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Research Article

An Aqueous Extract of Fagonia cretica Induces DNA Damage, Cell Cycle Arrest and Apoptosis in Breast Cancer Cells via FOXO3a and p53 Expression

  • Matt Lam,

    Affiliation: School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

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  • Amtul R. Carmichael,

    Affiliation: Russell Hall, Dudley Group Hospitals, Dudley, United Kingdom

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  • Helen R. Griffiths mail

    h.r.griffiths@aston.ac.uk

    Affiliation: School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

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  • Published: June 27, 2012
  • DOI: 10.1371/journal.pone.0040152

About the Authors

Matt Lam, Helen R. Griffiths
School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
Amtul R. Carmichael
Russell Hall, Dudley Group Hospitals, Dudley, United Kingdom

Corresponding Author

Email: h.r.griffiths@aston.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML HRG. Performed the experiments: ML. Analyzed the data: ML HRG. Contributed reagents/materials/analysis tools: HRG ARC. Wrote the paper: ML HRG.