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Research Article

Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses

  • Maria Håkanson,

    Affiliation: BioInterface Group, Laboratory for Surface Science and Technology, ETH Zurich, Zurich, Switzerland

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  • Stefan Kobel,

    Affiliation: Laboratory of Stem Cell Bioengineering, EPF Lausanne, Lausanne, Switzerland

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  • Matthias P. Lutolf,

    Affiliation: Laboratory of Stem Cell Bioengineering, EPF Lausanne, Lausanne, Switzerland

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  • Marcus Textor,

    Affiliation: BioInterface Group, Laboratory for Surface Science and Technology, ETH Zurich, Zurich, Switzerland

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  • Edna Cukierman mail,

    edna.cukierman@fccc.edu (EC); mirren.charnley@mat.ethz.ch (MC)

    Affiliation: Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, USA

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  • Mirren Charnley mail

    edna.cukierman@fccc.edu (EC); mirren.charnley@mat.ethz.ch (MC)

    Affiliation: BioInterface Group, Laboratory for Surface Science and Technology, ETH Zurich, Zurich, Switzerland

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  • Published: June 29, 2012
  • DOI: 10.1371/journal.pone.0040141

About the Authors

Maria Håkanson, Marcus Textor, Mirren Charnley
BioInterface Group, Laboratory for Surface Science and Technology, ETH Zurich, Zurich, Switzerland
Stefan Kobel, Matthias P. Lutolf
Laboratory of Stem Cell Bioengineering, EPF Lausanne, Lausanne, Switzerland
Edna Cukierman
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, USA

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MH MT EC MC. Performed the experiments: MH. Analyzed the data: MH MC. Contributed reagents/materials/analysis tools: SK MPL MT. Wrote the paper: MH MT EC MC.